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Frontiers Insight Into Metabolic Versatility of an

Introduction

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SDTMIG 3.3 New domains new benefitsCDISC

 · Table 2.2.12 Domain-Specific Variables for General Observation Class Domains MHEVDTYPMedical History Event Date Type MSAGENTAgent Name MSCONCAgent Concentration MSCONCUAgent Concentration Units Dataset Additions Table 4.1.5 Device-Subject Relationships Dataset Table 5.1.1 Device Identifiers Dataset

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Pharmacokinetic and Pharmacodynamic Analysis of

 · There was an approximately 4-fold increase in mean predose tocilizumab concentrations from week 2 to week 24. Steady-state predose tocilizumab concentration in week 24 was approximately 7.4 μg/mL. Results from the PK substudies are also included in Supplementary Tables S2 and S3.

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NucleoCounter YC-100™

 · The NucleoCounter® YC-100™ system is comprised of the NucleoCounter® automatic cell counter the NucleoCassette™ a cell preparation lysing buffer (Reagent Y100™) and NucleoView™ software for use with an optional computer interface. The NucleoCounter system enables the user to determine yeast cell concentration in

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Differential Effects of HIF-1 Inhibition by YC-1 on the

 · Hypoxia-inducible factor 1 (HIF-1) is a master regulator of cellular adaptation to hypoxia and has been suggested as a potent therapeutic target in cerebral ischemia. Here we show in an ischemic stroke model of rats that inhibiting HIF-1 and its downstream genes by 3-(5 -hydroxymethyl-2 -furyl)-1-benzylindazole (YC-1) significantly increases mortality and enlarges infarct volume evaluated by

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Rahul IyerProduct GrowthLendTable (YC S20)

 · Rahul Iyer Product Growth at LendTable (YC S20) ex-Facebook New York New York United States 500 connections

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MacChciacnopyrgCtPDnypoCPeCvcr w yc REVIEW

included flushing malaise and concentration problems started approximately three months earlier and improved when lying down and worsened when standing. Her sister and father had similar symptoms at the same age. We performed a tilt table test. Her supine blood pressure was 141/84 mmHg and her heart rate was 111 beats per minute (bpm).

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YC-1 BINDING TO THE BETA SUBUNIT OF SOLUBLE

YC-1 readily enhances CO binding in Ms sGC-NT proteins (Table 1 reference 33) which lack the cyclase domain but does not stimulate the isolated cyclase domains. 59 YC-1 also readily enhances CO binding to Ms sGC-NT21 (Table 1 reference 43) which does not contain the α 1 H-NOX domain ruling out the α 1 H-NOX domain as containing the

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A novel mode of action of YC-1 in HIF inhibition

Hypoxia-inducible factor (HIF)-1 plays a key role in tumor promotion by inducing ∼60 genes required for tumor adaptation to hypoxia thus it is viewed as a target for cancer therapy. For this reason YC-1 which down-regulates HIF-1α and HIF-2α at the post-translational level is being developed as a novel anticancer drug. We here found that YC-1 acts in a novel manner to inhibit HIF-1.

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Pharmacological HIF-inhibition attenuates postoperative

 · Fibroblasts were treated with different concentrations of YC-1 (0.1 μM 1 μM and 10 μM) or 1 DMSO while incubated in a hypoxia chamber (Billups-Rothenberg San

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(PDF) Biodegradation of endocrine disruptor Bisphenol A

 · Pseudomonas putida YC-AE1 showed high ability to degrade a wide range of BPA concentrations (0.5-1000 mg l−1) with completely degradation for 500 mg l−1 within 72 hours.

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Cellometer X2 Fluorescent Viability Counter Nexcelom

Concentration Dynamic Range Figure 1 depicts the dynamic range for cell concentration measured by Cellometer X2. This data set was taken on a concentration series of cultured yeasts. Samples from 2.5 x 10 55 x 10 7 cells/ml can be counted without further dilution. The CV at each concentration

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Real-time and on-line monitoring of ethanol fermentation

 · In this study introduction of a viable cell sensor and electronic nose into ethanol fermentation was investigated which could be used in real-time and on-line monitoring of the amount of living cells and product content respectively. Compared to the conventional off-line biomass determination the capacitance value exhibited a completely consistent trend with colony forming units

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YC-1 a novel activator of platelet guanylate

YC-1 3-(5 -hydroxymethyl-2 -furyl)-1-benzylindazole inhibited the aggregation of and ATP release from washed rabbit platelets induced by arachidonic acid (AA) collagen U46619 platelet-activating factor (PAF) and thrombin in a concentration-dependent manner. YC-1 also disaggregated the clumped platelets caused by these inducers. The thromboxane B2 formation caused by collagen PAF and

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YC-1 a Novel Activator of Platelet Guanylate Cyclase

 · YC-1 (1.5 to 150 µmol/L) PGE 1 (1 µmol/L) and sodium nitroprusside (10 µmol/L) also inhibited in a concentration-dependent manner the ATP release caused by these five inducers. Inhibition of ATP release was parallel to inhibition of platelet aggregation (data not shown). However YC-1 (150 µmol/L) PGE (1 and 10 µmol/L) and sodium nitroprusside (1 mmol/L) did not affect the platelet

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IJERPH Free Full-Text Biodegradation of Di (2

In this series of experiments the degradation efficiency of YC-IL-1 was assessed using different concentrations of DEHP (lower concentration (1 2 5 and 10 mg/L) or higher concentration (50 100 200 300 400 500 and 1000 mg/L)) in order to determine the minimum and maximum concentration of DEHP that can be degraded by YC-IL-1.

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Yeast culture promotes the production of aged laying hens

 · Yeast culture (YC) positively affects the performance of laying hens.The purpose of the present study was to explore the underlying mechanism for the YC-mediated performance improvement. Sixty 67-week-old Hy-Line Brown laying hens were randomly allocated into 2 experimental groups with 5 replicates of 6 birds each.

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SDTMIG 3.3 New domains new benefitsCDISC

 · Table 2.2.12 Domain-Specific Variables for General Observation Class Domains MHEVDTYPMedical History Event Date Type MSAGENTAgent Name MSCONCAgent Concentration MSCONCUAgent Concentration Units Dataset Additions Table 4.1.5 Device-Subject Relationships Dataset Table 5.1.1 Device Identifiers Dataset

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YC-1 a Novel Activator of Platelet Guanylate Cyclase

 · YC-1 (1.5 to 150 µmol/L) PGE 1 (1 µmol/L) and sodium nitroprusside (10 µmol/L) also inhibited in a concentration-dependent manner the ATP release caused by these five inducers. Inhibition of ATP release was parallel to inhibition of platelet aggregation (data not shown). However YC-1 (150 µmol/L) PGE (1 and 10 µmol/L) and sodium nitroprusside (1 mmol/L) did not affect the platelet

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YC-1 BINDING TO THE BETA SUBUNIT OF SOLUBLE

 · YC-1 Binding Relieves Inhibition of the β 1 Heme Domain by the α 1 H-NOX and PAS Domains. Perhaps our most unexpected finding is that the affinity of CO for heme in the β 1 H-NOX domain is as high in the absence of other domains as it is in the presence of YC-1 (Table 1).

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YC-1 Potentiates Nitric Oxide- and Carbon Monoxide

 · YC-1 a benzylindazole derivative was shown to activate sGC in intact platelets resulting in inhibition of platelet aggregation. In a previous study we demonstrated that YC-1 not only stimulates purified sGC but also potentiates the stimulatory action of submaximally effective NO and carbon monoxide (CO) concentrations.

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The activity coefficients of hydrofluoric acid in water

 · tain the values of K and k given in table 1. Plots of (ycA/b)2(c/(1-A/Ao)) against c(1-L/Lo) are shown in figure 1. Line A is obtained if no corrections are made for activity coefficients or changes in ionic mobilities with concentration i.e. (y/b)2 is unity. Line B is obtained if corrections are made for activity

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Biodegradation of phthalic acid esters by a newly isolated

 · Bacterial strain YC-RL4 capable of utilizing phthalic acid esters (PAEs) as the sole carbon source for growth was isolated from petroleum-contaminated soil. Strain YC-RL4 was identified as Mycobacterium sp. by 16S rRNA gene analysis and Biolog tests. Mycobacterium sp. YC-RL4 could rapidly degrade dibutyl phthalate (DBP) diethyl phthalate (DEP) dimethyl phthalate (DMP)

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Determinação de inosina 5 -monofosfato (IMP) e

Determinação de inosina 5 -monofosfato (IMP) e guanosina 5 -monofosfato (GMP) Abstract This study proposed a method to determine the sum of the concentrations of inosine 5 -monophosphate (IMP) and guanosine 5 -monophosphate (GMP) in final and intermediate products through a combination of UV spectroscopy and Table 1. Sample

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YC CHANG Professor (Full) Ph D Muroran Institute of

YC CHANG Professor (Full) Cited by 6 055 of Muroran Institute of Technology Muroran Read 216 publications Contact YC CHANG

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YC-1 Induces S Cell Cycle Arrest and Apoptosis by

 · To determine effective YC-1 concentrations the Hep3B tumor-bearing mice were injected once with 30 mg/kg YC-1 and then YC-1 levels were measured in tumors. YC-1 was present in the range of 0.5 to 5 μmol/L in tumors 4 hours after injection ( Fig. 3 A ) suggesting that it has anticancer activity in this concentration range.

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Integrated systems for biopolymers and bioenergy

 · Recently issues concerning the sustainable and harmless disposal of organic solid waste have generated interest in microbial biotechnologies aimed at converting waste materials into bioenergy and biomaterials thus contributing to a reduction in economic dependence on fossil fuels. To valorize biomass waste materials derived from agriculture food processing factories and municipal organic

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Revised standard values for pH measurements from 0 to

 · two or more added small concentrations of a soluble chloride Yo CI is computed by the conven tion set forth in eq (1). The values of E O 2.30259RT/F and of the Debye­ Huckel slope A on the molal scale from 0 to 95 °C are summarized in table 1. For this calculation R was taken to be 8.3147 j mole-1 deg-I Fwas taken to

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r i na r yc Journal of VJournal of Veterinary Science

 · concentration of 0.25 μg mL–1 is accepted as maximum limit 21 . According to our results contents of Pb in 100 of samples analyzed present levels below the detection limits. As shown in Table 1 in males Pb concentration (0.1 ± 0.00 µg/ml) was significantly higher than females (0.08 ± 0.01 µg/ml). As shown in Table 2 although all of the

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Concentration-dependent radiosensitizing effect of

Cell cycle. First no obvious cell cycle change was observed below 6-h exposure to DTX at any concentration. After 12-h incubation of KES cells with the medium and high concentrations of DTX (5–50 nM and more) 65 of the cells were arrested in the G2-M phase with a 4-n content of DNA (Figs. 2 and 3 and Table I).The accumulation of cells in the sub-G0 and G0/G1 phases was observed after

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Complete genome sequence of Gordonia sp. YC-JH1 a

 · The isolated strain Gordonia sp.YC-JH1 could efficiently degrade a wide range of phthalic acid esters (PAEs).. This is the first report about complete genome sequence of Gordonia genus capable of degrading PAEs.. The novel hydrolase EstG1 against dialkyl PAEs is identified from Gordonia genus for the first time.. The complete pathway of PAEs metabolism is detected on the chromosome of strain

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SciELOBrasilTapioca starch films reinforced with

1 Introduction. Nowadays environmental pollution resulted from the usage of non-degradable materials such as petroleum-based materials for packaging applications is becoming crucial (Risyon et al. 2016 Risyon N. P. Othman S. H. Basha R. K. Talib R. A. (2016).Effect of halloysite nanoclay concentration and addition of glycerol on mechanical properties of bionanocomposite films.

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Anti-Somatostatin Antibody clone YC7 MAB354

Application. Anti-Somatostatin Antibody clone YC7 is an antibody against Somatostatin for use in IH. Key Applications. Immunohistochemistry. Application Notes. Immunohistochemistry at 1 50-1 100 on human brain. Optimal working dilutions must be determined by the end user. Biological Information. Immunogen.

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